High purity factor VIII concentrates and HIV infection.
نویسندگان
چکیده
منابع مشابه
Recombinant clotting factor VIII concentrates: Heterogeneity and high-purity evaluation.
Factor VIII is an important glycoprotein involved in hemostasis. Insertion of expression vectors containing either the full-length cDNA sequence of human factor VIII (FLrFVIII) or B-domain deleted (BDDrFVIII) into mammalian cell lines results in the production of recombinant factor VIII (rFVIII) for therapeutic usage. Three commercially available rFVIII concentrates (Advate, Helixate NexGen and...
متن کاملPurity of factor VIII concentrates and immune function in hemophiliacs.
The report by de Biasi et all is an important contribution to the debate regarding the possible role of product purity in modulating immune function in hemophiliacs. However, some aspects of the study bear comment. Patients treated with an intermediate-purity concentrate showed a deterioration in immune function compared with those treated with a high-purity product. The two products, however, ...
متن کامل6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates
6.5 Range of Application, Dosage, Mode of Administration 6.5.1 General Information 6.5.2 Indications for Replacement Therapy Using Factor Concentrates 6.5.3 Dosage, Mode of Administration 6.5.3.1 Replacement in Children with Hemophilia A, B or von Willebrand Syndrome 6.5.3.2 Replacement in Adults with Hemophilia A, B or von Willebrand Syndrome 6.5.3.3 Indications and Recommended Doses for Treat...
متن کامل6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates.
6.5 Range of Application, Dosage, Mode of Administration 6.5.1 General Information 6.5.2 Indications for Replacement Therapy Using Factor Concentrates 6.5.3 Dosage, Mode of Administration 6.5.3.1 Replacement in Children with Hemophilia A, B or von Willebrand Syndrome 6.5.3.2 Replacement in Adults with Hemophilia A, B or von Willebrand Syndrome 6.5.3.3 Indications and Recommended Doses for Treat...
متن کاملComparable modulation of human monocyte functions by commercial factor VIII concentrates of varying purity.
Our previous observation on immune modulation induced by a given factor VIII (F VIII) concentrate preparation was extended by showing that the immune-modulating capacity is a more general feature of F VIII products and is independent of product purity. Interaction of human monocytes with therapeutic concentrations of various F VIII concentrates (0.2 to 2 IU F VIII/mL, six different F VIII conce...
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ژورنال
عنوان ژورنال: BMJ
سال: 1992
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.304.6827.641